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HumaColl 21: A Vegan Human Collagen

HumaColl™ and HumaColl21 represents a groundbreaking advancement in the field of skincare and beauty products. Developed by Gettor, it stands as the first and only vegan biomimetic human type 21 collagen designed specifically for topical applications. This innovative ingredient is poised to revolutionize the beauty industry, offering a sustainable and effective alternative for enhancing skin health and appearance.

At the heart of HumaColl lies its unique formulation, which closely mimics the structure and function of human type 21 collagen. Unlike traditional collagen derived from animal sources, HumaColl21 is produced using biotechnology, ensuring a 100% match to the amino acid sequence of human type 21 collagen. This bioengineered approach not only ensures purity and safety but also maximizes the efficacy of the product.

With its biomimetic properties, HumaColl21 holds the potential to replenish and rejuvenate the skin, addressing common concerns such as fine lines, wrinkles, and loss of elasticity. By harnessing the power of biodesign and precision fermentation, HumaColl21 offers a novel solution for achieving a more youthful and radiant complexion.

Understanding Human Type 21 Collagen

To appreciate the significance of HumaColl21, it’s essential to understand the role of collagen in skin health. Collagen is the most abundant protein in the human body, providing structural support and resilience to various tissues, including the skin. Among the different types of collagen, human type 21 collagen stands out for its rarity and specialized functions.

Human type 21 collagen, although comprising less than 1% of the body’s collagen composition, plays a crucial role in maintaining skin integrity and youthfulness. As a signaling molecule, type 21 collagen stimulates the production of essential extracellular matrix components, including collagen, fibronectin, and elastin. These components contribute to the overall structure, firmness, and elasticity of the skin.

Compared to more well-known collagen types like type I and type III, type 21 collagen offers unique benefits for skin health. Its ability to boost extracellular matrix production makes it particularly effective in promoting a healthy and youthful appearance. By incorporating HumaColl21 into skincare formulations, beauty professionals can harness the full potential of human type 21 collagen to enhance the efficacy of their products.

The Science Behind HumaColl 21

HumaColl21’s efficacy stems from its innovative biodesign and precision fermentation processes, which enable it to closely mimic the structure and function of human type 21 collagen. By precisely replicating the amino acid sequence of human type 21 collagen, HumaColl21 interacts seamlessly with the skin’s natural processes, resulting in superior performance compared to traditional collagen-based products.

Upon application, HumaColl21 works by stimulating collagen and elastin production in the skin. This increase in extracellular matrix components helps to improve skin firmness, elasticity, and overall appearance. Additionally, HumaColl21 boosts endogenous hyaluronic acid levels, promoting optimal hydration and plumpness in the skin.

Through its unique mode of action, HumaColl21 has demonstrated remarkable efficacy in various preclinical and clinical studies. In vitro studies have shown significant increases in collagen type I production, outperforming even retinol-based treatments. Furthermore, HumaColl21 has been found to enhance hyaluronic acid expression and increase skin elasticity, leading to visible improvements in skin texture and tone.

Benefits of Using HumaColl

Integrating HumaColl into beauty products offers a multitude of benefits for both consumers and skincare professionals alike. Clinical studies have consistently demonstrated the efficacy of HumaColl21 in addressing key skin concerns and promoting overall skin health.

One of the primary benefits of HumaColl is its ability to improve skin complexion and texture. By stimulating collagen and elastin production, HumaColl21 helps to reduce the appearance of fine lines, wrinkles, and other signs of aging. Additionally, vegan collagen‘s hydrating properties enhance skin moisture levels, resulting in a smoother and more radiant complexion.

Moreover, HumaColl has been shown to have anti-inflammatory properties, making it effective in reducing skin redness and irritation. This makes it suitable for individuals with sensitive or reactive skin types, providing relief from common skincare concerns.

Overall, HumaColl21 represents a versatile and efficacious ingredient for beauty products, offering a holistic solution for achieving healthy, youthful-looking skin. Its ability to deliver clinically proven results makes it a valuable asset for skincare products and a must-have for beauty industry professionals.

Application of HumaColl 21 in Beauty Products

Beauty industry professionals can leverage the versatility of HumaColl 21 by incorporating it into a wide range of skincare and personal care products. Its compatibility with various formulations makes it suitable for diverse applications, including:

  • Skin Care: HumaColl can be integrated into serums, moisturizers, creams, and masks to target specific skin concerns and deliver visible results.
  • Body Care: Body lotions, oils, and treatments can benefit from the hydrating and firming properties of HumaColl 21, promoting overall skin health and vitality.
  • Color Cosmetics: Foundations, concealers, and other makeup products can be enhanced with HumaColl21 to provide additional skincare benefits and a smoother application.
  • Grooming: HumaColl 21 can be incorporated into grooming products such as beard oils and shaving creams to soothe and nourish the skin, enhancing the overall grooming experience.

By formulating products with HumaColl21, beauty professionals can cater to the growing demand for clean and effective skincare solutions. Its biodesigned nature ensures compliance with clean beauty standards, making it an ideal choice for cosmetics and skincare brands committed to sustainability and innovation.


HumaColl, like Caviance, represents a significant advancement in the field of skincare, offering beauty industry professionals a sustainable and effective solution for addressing key skin concerns. By harnessing the power of biodesign and precision fermentation, HumaColl21 delivers clinically proven results, promoting healthier, more youthful-looking skin.

With its biomimetic properties and versatile applications, HumaColl 21 is poised to become a staple ingredient in next-generation beauty products. Its ability to stimulate collagen production, boost hyaluronic acid levels, and improve skin elasticity makes it an invaluable asset for skincare formulations.

Beauty professionals are encouraged to explore the potential of HumaColl21 and incorporate it into their product formulations to unlock its full benefits. As consumer demand for clean, sustainable beauty continues to grow, HumaColl 21 offers a compelling solution that meets both efficacy and ethical standards.

HumaColl and Human Collagen References

COL21A1 collagen type XXI alpha 1 chain

A Review of the Effects of Collagen Treatment

The Collagen Family – PMC